Study to Evaluate the Safety and Efficacy of Teropavimab and Zinlirvimab in Combination With Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection
Completed · Phase 1
Conditions studied: HIV-1 Infection
In brief
The primary objective of this study is to evaluate the safety and tolerability of a combination of the broadly neutralizing antibodies (bNAbs) teropavimab (formerly GS-5423) and zinlirvimab (formerly GS-2872) in combination with the HIV capsid inhibitor lenacapavir (LEN).
Key facts
- Study ID
- NCT04811040
- Run by
- Gilead Sciences
- People needed
- 32
- Starts
- 2021-04-08
- Expected to finish
- 2023-10-26
- Last updated by the study team
- 2025-01-27
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Ruane Clinical Research Group Inc. — Los Angeles, California, United States
- Mills Clinical Research — Los Angeles, California, United States
- One Community Health — Sacramento, California, United States
- UCSD AntViral Research Center (AVRC) — San Diego, California, United States
- Yale University; School of Medicine; AIDS Program — New Haven, Connecticut, United States
- Midway Immunology and Research Center — Ft. Pierce, Florida, United States
- University of Miami Miller School of Medicine Schiff Center for Liver Disease — Miami, Florida, United States
- Orlando Immunology Center — Orlando, Florida, United States
- Triple O Research Institute, P.A — West Palm Beach, Florida, United States
- Mercer University, Department of Internal Medicine — Macon, Georgia, United States
- Indiana CTSI Clinical Research Center — Indianapolis, Indiana, United States
- National Institutes of Health/Clinical Center — Bethesda, Maryland, United States
- Be Well Medical Center — Berkley, Michigan, United States
- AXCES Research Group — Santa Fe, New Mexico, United States
- Icahn School of Medicine at Mount Sinai-Clinical and Translational Research Center — New York, New York, United States
- NC TraCS Institute-CTRC; University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- The Brody School of Medicine at East Carolina University, ECU Adult Specialty Care — Greenville, North Carolina, United States
- Rosedale Health & Wellness — Huntersville, North Carolina, United States
- Perelman Center for Advanced Medicine at the Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Central Texas Clinical Research — Austin, Texas, United States
- The Crofoot Research, INC. — Houston, Texas, United States
- Peter Shalit, M.D. — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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