Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Recruiting now · Not applicable

Conditions studied: Cannabis, HIV, Inflammation, Cognition, Neuroimaging

In brief

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Key facts

Study ID

NCT04810858

Run by

Wake Forest University Health Sciences

People needed

220

Starts

2021-08-18

Expected to finish

2027-05-31

Last updated by the study team

2026-03-31

Who can join

Age: 25 and older, up to 59. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• verified HIV status
• Current marijuana use (MJ+ groups only)
• No current marijuana use (MJ- groups only)
• current engagement in HIV care (HIV+ participants only)
• receipt of cART as first-line of treatment (HIV+ participants only)
• stable cART regimen (HIV+ participants only)
• undetectable HIV RNA viral load for >1 year (HIV+ participants only)

You may not qualify if…

• Lifetime abuse for any illicit drug other than marijuana
• <9th grade education; illiteracy or lack of fluency in English
• history of moderate or severe head trauma
• unstable or serious neurological disorders
• severe mental illness
• systemic autoimmune diseases
• immunotherapy
• MRI contraindications

Where it is running

• Biotech Place — Winston-Salem, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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