Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting.

Withdrawn before enrolling · Phase 4 · Has a placebo group

Conditions studied: Postoperative Nausea and Vomiting

In brief

Postoperative nausea and vomiting (PONV) are common and continue to be persistent problems following general anesthesia. Intranasal lidocaine has been used for the treatment of migraine. The theoretical basis for this effect of intranasal lidocaine on migraine relief is reported to be due to its action on the sodium receptors within the sphenopalatine ganglion. Although there is no reported association between PONV and migraines, injecting lidocaine within the sphenopalatine ganglion has proven to be effective in reducing PONV in endoscopic sinus surgery. The purpose of this study is to investigate the efficacy of intranasal 2% lidocaine in preventing PONV.

Key facts

Study ID

NCT04810494

Run by

Milton S. Hershey Medical Center

People needed

0

Starts

2022-10-01

Expected to finish

2023-06-30

Last updated by the study team

2022-12-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ≥18 years of age
• ASA Physical status I-III
• Ability to provide informed consent
• Pre-surgical COVID-19 negative test
• Elective, non-cardiac surgery under general anesthesia including breast surgery, gynecologic surgery, and minimally invasive abdominal surgery

You may not qualify if…

• Local anesthetic allergy
• Liver diseases
• Pregnancy
• Current tobacco use
• Pre-existing disorders of the gastrointestinal tract
• Use of anti-emetics within 48 h prior to surgery
• Chronic use of anti-cholinergic medication or chronic treatment with opioids
• Any history of nasal pathology (e.g. Nasal ulcer, polyps, and rhinitis)
• Actual surgical time of <30 min or >180 min
• Recovery from anesthesia in any location other than PACU
• History of PONV
• History of motion sickness
• Receiving regional blocks for pain management
• Use of total intravenous anesthesia (TIVA) and/or propofol infusion throughout the case
• Aprepitant (Emend) administration
• Non-English speaking patients

Where it is running

• Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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