Tracking Neural Synergies After Stroke.

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Conditions studied: Stroke

In brief

The purpose of this study is to identify neural muscle synergies of patients post-stroke and track them during an inpatient acute rehabilitation. To this end, the researchers will use an innovative approach based on the identification of large populations of motor units from recordings of surface high-density electromyography (HD-EMG).

Key facts

Study ID

NCT04805866

Run by

Shirley Ryan AbilityLab

People needed

36

Starts

2021-06-09

Expected to finish

2026-07-15

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-85 years old
• Ambulatory with or without an assistive device
• Ability to stand unassisted for at least 15 min
• Informed consent provided by participant
• English speaking

You may not qualify if…

• Inability to communicate with researchers
• Lower extremity joint pain, contractures
• Major sensory deficits, or cardiovascular or respiratory symptoms contraindicative of walking
• History or evidence of orthopedic, muscular, or physical disability
• Taking current medications that may affect balance
• History or evidence of vestibular, auditory, or proprioceptive impairment
• History or indication of orthostatic hypotension
• History of any neurological disease
• Open wounds on surfaces in contact with HD-EMG electrodes
• Concurrent participation in other lower limb research studies that according to the PI is likely to affect study outcome or confound results
• Pregnancy
• Patients:
• Inclusion Criteria:
• Age 18-85 years old
• Unilateral, supratentorial ischemic or hemorrhagic stroke within the past six months
• Medical clearance from primary medical team (signed Medical Clearance form)
• Unassisted sitting balance at edge of mat or hospital bed ≥ 30 seconds
• Baseline Visible muscle contraction in hip flexors, knee extensors, and ankle dorsiflexors ( ≥1 MMT) or manual resistance against one muscle group (>3 MMT)
• Adequate cognitive function as determined by the NIH scale: score ≤1 on question 1b and score =0 on question 1c
• Informed consent provided by participant or POA
• English speaking
• Exclusion Criteria:
• Severe aphasia limiting ability to express needs or discomfort verbally or nonverbally
• Severe behavioral neglect
• History of prior stroke

Where it is running

• Shirley Ryan AbilityLab — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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