Study of Pain Catastrophizing-2 (SPAC-2)

Completed · Not applicable

Conditions studied: Osteoarthritis, Knee

In brief

This study experimentally manipulates pain catastrophizing in order to investigate the neural mechanisms by which pain catastrophizing influences the experience of pain in different ethnic groups among adults with knee osteoarthritis. Participants will be randomized to either a single session cognitive-behavioral intervention to reduce pain catastrophizing or a pain education control group.

Key facts

Study ID

NCT04805190

Run by

University of Florida

People needed

99

Starts

2021-10-15

Expected to finish

2023-12-12

Last updated by the study team

2024-05-14

Who can join

Age: 45 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptomatic knee OA

You may not qualify if…

• Younger than 45 years of age or older than 85 years of age
• Prosthetic knee replacement or other clinically significant surgery to the arthritic knee
• Uncontrolled hypertension (>150/95)
• Heart disease including heart failure
• Peripheral neuropathy in which pain testing was contraindicated
• Systemic rheumatic disorders including rheumatoid arthritis, systemic lupus erythematosus, gout, and fibromyalgia
• Neurological diseases such as Parkinson's, multiple sclerosis, stroke with loss of sensory or motor function, or uncontrolled seizures
• Significantly greater pain in body sites other than in the knee
• Daily opioid use
• Hospitalization within the preceding year for psychiatric illness
• Currently pregnant or nursing/breastfeeding

Where it is running

• UF Health at the University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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