Dose-Escalated Spine SbRT for Localized Metastasis to the Spinal Column
Recruiting now · Not applicable
Conditions studied: Spine Metastases, Metastasis Spine
In brief
This study is being done to determine the feasibility and tolerability of a novel regimen of spine stereotactic radiosurgery (SSRS). SSRS delivers high doses of radiation to tumors of the spine using precision techniques. In standard medical care, conventional SSRS is delivered in only 1 or 2 treatments. When this treatment is delivered in only 1-2 treatments, a high dose is used which can increase the side effects of treatment. This study aims to test an alternative technique of delivering SSRS over 5 treatments. By delivering the radiation therapy over multiple treatments, the dose of radiation is less per treatment.
Key facts
- Study ID
- NCT04802603
- Run by
- Baptist Health South Florida
- People needed
- 60
- Starts
- 2021-03-14
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2025-11-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Zubrod Performance Status 0-2
- Localized spine metastasis from a solid tumor from the C1 to L5 levels (a solitary spine metastasis, two separate spine levels, or up to 3 separate sites; each of the separate sites may have a maximal involvement of 2 contiguous vertebral bodies)
- Patients with epidural extension are eligible as long as there is a ≥ 2 mm gap between the spinal cord and the edge of the epidural lesion
- Paraspinal disease extension is allowed as long as it measures ≤ 5 cm in the greatest dimension and that it is contiguous with the spine metastasis
- For patients enrolled in cohort 2, the minimum time to re-irradiation should be 6 months
- Numerical Rating Pain Scale (NRPS) score of ≥ 5 at the index site(s) (as rated when the patient is not taking pain medication)
You may not qualify if…
- Radiosensitive histologies (myeloma, lymphoma, germ cell tumors, small cell lung cancer)
- Non-ambulatory patients
- >50% loss of vertebral body height or spinal instability to due pathologic compression fracture
- Frank spinal cord compression, spinal cord displacement, or epidural extension within 2 mm of the spinal cord
- Rapid neurologic decline
- Patients for whom an MRI of the spine is medically contraindicated
- Pregnant women
Where it is running
- Miami Cancer Institute at Baptist Health, Inc — Miami, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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