Dexamethasone for Post Traumatic Headache

Completed · Phase 4 · Has a placebo group

Conditions studied: Post-Traumatic Headache

In brief

This is a randomized study of intravenous metoclopramide + intravenous dexamethasone versus intravenous metoclopramide for patients with acute post-traumatic headache.

Key facts

Study ID

NCT04799015

Run by

Montefiore Medical Center

People needed

162

Starts

2021-06-25

Expected to finish

2024-12-22

Last updated by the study team

2026-05-15

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet International Classification of Headache Disorders (3rd edition) criteria for acute post-traumatic headache as follows:
• Traumatic injury to the head has occurred
• Headache has developed within 7 days of injury to the head
• Headache is not better accounted for by another diagnosis (e.g., migraine or tension-type headache)
• The headache must be rated as moderate or severe in intensity at the time of initial evaluation

You may not qualify if…

• More than ten days have elapsed since the head trauma
• Headache has already been treated with an anti-dopaminergic medication
• Medication allergies
• Contra-indications including pheochromocytoma, seizure disorder, Parkinson's disease, use of Monoamine oxidase (MAO) inhibitors, and use of anti-rejection transplant medications

Where it is running

• Montefiore — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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