Combined CBIT and rTMS to Improve Tourette's Syndrome

Completed · Not applicable

Conditions studied: Tourette Syndrome

In brief

The investigator will apply 16 sessions of repetitive transcranial magnetic stimulation (rTMS) over 4 consecutive days for adult patients suffering from Tourette's Syndrome. Following rTMS, patients will undergo 8 sessions of Comprehensive Behavioral Intervention for Tics (CBIT) over 10 weeks via telemedicine. Clinical improvement in tic severity will be the primary outcome measure. Secondary outcome measures including underlying physiological effects will be measured via functional magnetic resonance imaginge (fMRI), high-density electroencephalograhy (HD-EEG), and TMS.

Key facts

Study ID

NCT04795908

Run by

University of Florida

People needed

3

Starts

2021-12-17

Expected to finish

2023-01-18

Last updated by the study team

2024-04-30

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient diagnosed with Tourette Syndrome > 18 years of age with moderate tic severity.
• Participants will be allowed to continue oral medications that they are taking for TS concurrently but will not be allowed to change their concurrent medication regimen throughout the duration of the study

You may not qualify if…

• Presence of metallic objects or neurostimulators in the brain
• Pregnancy
• History of active seizures or epilepsy
• Contraindications to receiving fMRI, such as claustrophobia
• Inability to participate in CBIT due to other underlying cognitive or medical condition

Where it is running

• Fixel Neurologic Institute — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.