Regional Phenotyping of CF and Non-CF Bronchiectasis

Recruiting now

Conditions studied: Cystic Fibrosis, Non-CF Bronchiectasis

In brief

The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.

Key facts

Study ID

NCT04793867

Run by

Children's Hospital Medical Center, Cincinnati

People needed

100

Starts

2021-02-08

Expected to finish

2027-03-31

Last updated by the study team

2025-02-20

Who can join

Age: 5 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• CF Patients: Diagnosis of CF based on sweat chloride >60 mMol/l
• Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
• Age minimum 5 years.
• Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.

You may not qualify if…

• Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
• Pregnancy or lactation.
• Inclusion Criteria of Healthy Subjects:
• Subjects 5 years of age and older with no known history of cardiopulmonary disease.
• Exclusion Criteria of Healthy Subjects:
• Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
• Pregnancy or lactation.

Where it is running

• Penny New — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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