Cognition and the Immunology of Postoperative Outcomes

Status unconfirmed

Conditions studied: Cognitive Impairment, Frail Elderly Syndrome, Delirium, Surgery

In brief

This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). The overarching goal of this application therefore is to define and better understand the clinical immunology underlying the relationship between cognition and geriatric surgical morbidity.

Key facts

Study ID

NCT04792983

Run by

Brigham and Women's Hospital

People needed

600

Starts

2019-09-06

Expected to finish

2025-07-31

Last updated by the study team

2021-03-12

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 65 years of age
• American Society of Anesthesiologists (ASA) physical status of I-III
• Scheduled for elective spine surgery.

You may not qualify if…

• History of stroke (not including transient ischemic attacks, or TIAs)
• History of brain tumor
• History of autoimmune disorders
• Medications likely to significantly impact inflammation (e.g. steroids)
• Current infection
• Uncorrected vision or hearing impairment
• limited use of the dominant hand (limited ability to draw)
• inability to speak, read, or understand English.

Where it is running

• Brigham & Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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