Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

Completed · Phase 2

Conditions studied: Pain, Postoperative, Narcotic Use

In brief

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery.

Key facts

Study ID

NCT04791943

Run by

Montefiore Medical Center

People needed

60

Starts

2021-11-16

Expected to finish

2025-10-20

Last updated by the study team

2026-01-30

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation
• Ages 18-35
• American Society of Anesthesiologists (ASA) Class I or II
• English or Spanish speaking patients
• Capacity to sign informed consent

You may not qualify if…

• Allergies to melatonin, opioids, or other Over-the-counter (OTC) pain medications
• Anyone currently taking melatonin for any reason
• Cases under local anesthesia
• ASA class III or higher
• Sleep disorder (insomnia/narcolepsy)
• Current or past history of substance abuse
• Chronic pain
• Language/communication barrier
• Psychiatric disease/ Mental impairment
• Current or past use of psychotropic drugs
• Pregnancy
• Renal or hepatic impairment
• BMI >35

Where it is running

• Montefiore Medical Center Department of Dentistry — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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