Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Recruiting now · Not applicable
Conditions studied: Type 2 Diabetes, Overweight and Obesity
In brief
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Key facts
- Study ID
- NCT04791371
- Run by
- University of Colorado, Denver
- People needed
- 150
- Starts
- 2022-06-17
- Expected to finish
- 2027-02-15
- Last updated by the study team
- 2026-03-23
Who can join
Age: 30 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Sedentary (defined as less than 1 hour per week of physical activity)
- BMI: 25-40
- Men and women with and without type 2 diabetes
You may not qualify if…
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) > 150, diastolic blood pressure (DBP)> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment that would limit exercise ability
- Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 1 years
- Current tobacco use
- Anemia
- Control HbA1c > 5.7, T2DM HbA1c > 9
- Pregnant, nursing or hormonal therapy (other than contraceptives)
- Peri or post-menopausal women
- Type 1 diabetes
- Hepatic or renal disease.
Where it is running
- University of Colorado — Aurora, Colorado, United States (enrolling)
- University of Virginia — Charlottesville, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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