Pullback Pressure Gradient (PPG) Global Registry

Running, not enrolling

Conditions studied: Chronic Coronary Insufficiency, Non ST Elevation Myocardial Infarction

In brief

The purpose of this study is to determine the predictive capacity of the Pullback Pressure Gradient (PPG) index for post-PCI FFR and to determine the impact of the PPG index on clinical decision making about revascularization and on clinical outcomes.

Key facts

Study ID

NCT04789317

Run by

VZW Cardiovascular Research Center Aalst

People needed

982

Starts

2020-12-23

Expected to finish

2026-12-31

Last updated by the study team

2024-10-15

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Consecutive patients with stable coronary artery disease or stabilized acute coronary syndrome and invasive FFR measurement ≤0.80.

You may not qualify if…

• Angiographic exclusion criteria
• Ostial lesions.
• Severe vessel tortuosity.
• Vessel rewiring deemed 'difficult' by the operator.
• Bifurcation with planned two-stent strategy.
• NSTEMI culprit vessel.
• STEMI
• Uncontrolled or recurrent ventricular tachycardia.
• Hemodynamic instability
• Severe renal dysfunction, defined as an eGFR <30 mL/min/1.73 m2

Where it is running

• Stanford University — Stanford, California, United States
• St Francis Hospital and Heart Center — New York, New York, United States
• Memorial Hermann Texas Medical Center — Texas City, Texas, United States
• Monash Medical Center — Melbourne, Australia
• Concord Repatriation General Hospital — Sydney, Australia
• OLV Aalst — Aalst, Belgium
• Aalborg University Hospital — Aalborg, Denmark
• Aarhus University Hospital — Aarhus, Denmark
• Righospitalet — Copenhagen, Denmark
• Institut Arnault Tzanck — Nice, France
• Ferrara University — Ferrara, Italy
• Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome, Italy
• Aichi University — Aichi, Japan
• Gifu Heart Center — Gifu, Japan
• Showa University Hospital — Tokyo, Japan
• Tokyo D Tower Hospital — Tokyo, Japan
• Catharina Ziekenhuis — Eindhoven, Netherlands
• Radboud UMC — Nijmegen, Netherlands
• Hospital Clinico San Carlos — Madrid, Spain
• Hospital Universitario de La Princesa — Madrid, Spain
• Karolinska Institutet — Stockholm, Sweden
• CHUV — Lausanne, Switzerland
• Guy and St Thomas NHS Foundation Trust — London, United Kingdom

Full record on ClinicalTrials.gov

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