The Impact of Prednisone on Semen Parameters and Pregnancy Rates Post Vasectomy Reversal

Running, not enrolling · Phase 4

Conditions studied: Vasectomy Reversal

In brief

1. Determine impact of prednisone on semen parameters post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 2. Determine impact of prednisone on pregnancy rates post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 3. Assess adverse events with prednisone utilization

Key facts

Study ID

NCT04788823

Run by

Charitable Union for the Research and Education of Peyronie's Disease

People needed

100

Starts

2021-02-24

Expected to finish

2026-02-01

Last updated by the study team

2025-02-13

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Men undergoing a first-time vasectomy reversal at the Male Fertility and Peyronie's Clinic
• 18-65 years of age
• Current sexual partner with desire to achieve pregnancy immediately
• Intent of reversal to restore fertility
• Partner <36 years of age
• Partner with no known fertility issues
• Prior history of paternity

You may not qualify if…

• Current corticosteroid use
• Prior vasectomy reversal
• Prior chemotherapy
• Testosterone use within 1 year of the vasectomy reversal
• Solitary testicle
• History of diabetes mellitus
• History of systemic fungal infection
• Hypertension
• Any degree of diagnosed renal insufficiency
• Partner on birth control within past 3 months

Where it is running

• Cure PD — Orem, Utah, United States

Full record on ClinicalTrials.gov

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