A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Chronic Rhinosinusitis With Nasal Polyps

In brief

This study will evaluate the effect of CBP-201, rademikibart, in adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).

Key facts

Study ID

NCT04783389

Run by

Connect Biopharm LLC

People needed

40

Starts

2021-06-16

Expected to finish

2022-06-10

Last updated by the study team

2023-10-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Female and male patients aged ≥ 18 and ≤ 75 years at the time of screening.
• Patients who are diagnosed with chronic rhinosinusitis with bilateral polyps despite treatment with systemic corticosteroid within the past 2 years and/or medical contraindication/intolerance to systemic corticosteroids. The polyps have a minimum bilateral nasal polyps score (NPS) of 5 out of a maximum score of 8 with at least a score of 2 for each nostril at screening and baseline evaluated by endoscopy.
• Nasal congestion/blockade/obstruction with moderate or severe symptom severity (Nasal Congestion Score of > 2) at screening and a weekly average severity of > 1 at time of randomization.
• Patients using a documented stable dose of nasal mometasone at least 200 mcg/day, or an equivalent daily dose of another inhaled nasal corticosteroid (INCS), for at least 28 days before randomization and willing to continue the dose for the duration of the study. Note: For patients who are using an alternative INCS product other than mometasone furoate nasal spray (MFNS) prior to the screening visit, the investigator must switch the patient to MFNS at V1.
• Patients willing to enter Patient Diary daily symptom assessments and maintain stable dosing with MFNS with a compliance of at least 70% in the 7 days preceding randomization. Note: Patients must use nasal mometasone at least 200 mcg/day, or equivalent, for at least 28 days before randomization, which can include days prior to screening with supportive documentation. Run-in can be 7-31 days with the compliance determined in the week prior to dosing.
• Male patients who are non-sterilized and sexually active with a female partner of childbearing potential agree to use highly effective contraception from randomization until 8 weeks after last dose.
• Female patients of childbearing potential who are sexually active with a nonsterilized male partner should have a confirmed negative serum beta-human chorionic gonadotropin test at Visit 1 and agrees to use highly effective contraception from signing of informed consent throughout the duration of the study and for 8 weeks after last dose.
• Patient is able to understand and willing to sign the informed consent form (ICF) prior to any study related procedures being performed.
• Willing and able to comply with all study visits and study-related procedures, in the opinion of the Investigator.

You may not qualify if…

• A patient who meets any of the following criteria will be ineligible to participate in this study:
• Patients unable to use MFNS.
• Patients who are taking or have taken the following prohibited therapies as specified:
• Systemic steroids within 28 days prior to screening,
• Other nonbiologic investigational drugs within 60 days (or 5 half-lives, whichever is longer) of screening,
• Intranasal corticosteroid drops or corticosteroid-administering devices (eg, OptiNose device or stents) within 28 days prior to screening,
• Non-steroidal immunosuppressants (eg, cyclosporine, methotrexate, azathioprine, mycophenolate, sirolimus, tacrolimus) within 60 days or 5 half-lives, whichever is longer, of screening,
• Any monoclonal antibody therapy (eg, benralizumab, mepolizumab, omalizumab, reslizumab, dupilumab) or investigational biologic drug for asthma or other diseases within 60 days or 5 half-lives, whichever is longer, of screening,
• Leukotriene antagonists/modifiers within 7 days prior to screening for patients who were not on continuous treatment for ≥ 30 days prior to screening,
• Allergen immunotherapy for patients who were not on maintenance treatment for at least 90 days prior to screening
• Patients who did not respond favorably to previous dupilumab treatment (eg, therapy failure or patient experienced an adverse reaction to treatment).
• Patients who have undergone any nasal surgery (including polypectomy) within 6 months before screening; or have a history of sinus or nasal surgery modifying the structure of the nose such that assessment of NPS is not possible, or have had uncontrolled epistaxis requiring surgical or procedural intervention, including nasal packing.
• Patients with conditions/concomitant diseases making them non evaluable at screening or for the primary efficacy endpoint such as: antrochoanal polyps, nasal septal deviation that would occlude at least 1 nostril, acute sinusitis, nasal infection or upper respiratory infection at screening or within 2 weeks before screening, ongoing rhinitis medicamentosa; known or suspected diagnosis of cystic fibrosis; chronic granulomatous disease and granulomatous vasculitis, granulomatosis with polyangiitis (Wegener's Granulomatosis), eosinophilic granulomatous with polyangiitis (Churg-Strauss syndrome), Young's syndrome, primary dyskinetic ciliary syndromes (eg, Kartagener's syndrome) or other dyskinetic ciliary syndromes.
• Signs or a CT scan suggestive of Allergic Fungal Rhinosinusitis.
• Patients with co-morbid asthma are excluded if:
• Forced Expiratory Volume in 1 second (FEV1) ≤ 50% of normal predicted value OR
• An exacerbation within 90 days prior screening that required hospitalization (> 24 hours) OR
• Are on a daily dose of inhaled corticosteroids (ICS) higher than 1000 mcg fluticasone or the equivalent.
• Known or suspected history of immunosuppression, including history of invasive opportunistic infections, such as aspergillosis, coccidioidomycosis, histoplasmosis, human immunodeficiency virus (HIV), listeriosis, pneumocystosis, or tuberculosis, despite infection resolution; or unusually frequent, recurrent or prolonged infections. Tuberculosis testing would be performed on a country-by-country basis according to local guidelines if required by regulatory authorities or ethics committees.
• Patients who have active Hepatitis B, Hepatitis C or HIV infections as determined by positive results at Screening for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb); or hepatitis C (HCV) antibody; or positive HIV serology. Note: Patients who test positive for HBvAb, negative for HBsAg and subsequently confirmed positive for HBsAb, indicating resolved natural infection (confirmed by negative HBV-DNA), may participate. Patients with positive HCV may participate if subsequent viral load is confirmed negative.
• A helminth parasitic infection diagnosed within 24 weeks prior to the date of informed consent that has not been treated, or has failed to respond to, standard of care therapy.
• Evidence of infection requiring treatment with systemic antibacterials, antivirals, antifungals, antiparasitics, or antiprotozoals within 7 days before baseline, or viral infections within 14 days before screening that may not have received antiviral treatment.
• Live, attenuated vaccinations within 28 days prior to screening or planned live, attenuated vaccinations during the study.
• Pregnant or intent to become pregnant during the study, or breast-feeding women.
• Any disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric, or major physical impairment that is not stable in the opinion of the investigator and may affect the safety of the patient throughout the study, or influence the findings of the studies or their interpretations, or impede the patient's ability to complete the entire duration of study.

Where it is running

• Connect Investigative Site 124 — Bakersfield, California, United States
• Connect Investigative Site 125 — La Mesa, California, United States
• Connect Investigative Site 134 — Los Angeles, California, United States
• Connect Investigative Site 128 — Temecula, California, United States
• Connect Investigative Site 119 — Torrance, California, United States
• Connect Investigative Site 114 — Miami, Florida, United States
• Connect Investigative Site 109 — Miami, Florida, United States
• Connect Investigative Site 116 — Tampa, Florida, United States
• Connect Investigative Site 111 — Chicago, Illinois, United States
• Connect Investigative Site 126 — Chicago, Illinois, United States
• Connect Investigative Site 132 — Louisville, Kentucky, United States
• Connect Investigative Site 110 — White Marsh, Maryland, United States
• Connect Investigative Site 121 — Ann Arbor, Michigan, United States
• Connect Investigative Site 127 — St Louis, Missouri, United States
• Connect Investigative Site 102 — Princeton, New Jersey, United States
• Connect Investigative Site 105 — Rochester, New York, United States
• Connect Investigative Site 113 — The Bronx, New York, United States
• Connect Investigative Site 117 — Winston-Salem, North Carolina, United States
• Connect Investigative Site 123 — Cincinnati, Ohio, United States
• Connect Investigative Site 133 — Columbus, Ohio, United States
• Connect Investigative Site 112 — Tulsa, Oklahoma, United States
• Connect Investigative Site 122 — Tulsa, Oklahoma, United States
• Connect Investigative Site 108 — Charleston, South Carolina, United States
• Connect Investigative Site 107 — Memphis, Tennessee, United States
• Connect Investigative Site 130 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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