Loupe-Based Intraoperative Fluorescence Imaging

Recruiting now

Conditions studied: Glioblastoma Multiforme, Anaplastic Astrocytoma

In brief

Glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) are the most common primary malignant brain tumors. Survival of patients with these brain tumors is directly related to the extent of resection. Consequently, a great deal of effort has been directed at developing techniques and technologies that allow more extensive, safe resections. This study will test a loupe-based wearable device in the clinical setting and compare its accuracy with a large operative microscope to identify tumor tissues. Postoperative histopathological analysis on tumor tissues will be used as gold standards for comparison. The outcome from this study will be a low-cost, miniaturized, easy-to-operate, loupe-based fluorescence imaging device for intraoperative guidance of brain tumor resection with the same level of accuracy as the large microscope.

Key facts

Study ID

NCT04780009

Run by

Guoqiang Yu

People needed

30

Starts

2017-11-17

Expected to finish

2027-08-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults with brain malignant gliomas undergoing resection
• at least 18 years of age
• able to understand the consent

You may not qualify if…

• pregnant women
• under 18 years of age
• patients undergoing emergency surgery
• inability to give consent due to dysphagia or language barrier

Where it is running

• University of Kentucky — Lexington, Kentucky, United States (enrolling)

Full record on ClinicalTrials.gov

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