Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated
Stopped early · Phase 3
Conditions studied: Acute Myeloid Leukemia
In brief
The goal of this clinical study is to compare the effectiveness of the study drugs, magrolimab in combination with azacitidine, versus venetoclax in combination with azacitidine in participants with previously untreated TP53 mutant acute myeloid leukemia (AML).
Key facts
- Study ID
- NCT04778397
- Run by
- Gilead Sciences
- People needed
- 258
- Starts
- 2021-07-01
- Expected to finish
- 2024-03-25
- Last updated by the study team
- 2025-02-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope (City of Hope National Medical Center, City of Hope Medical Center) — Duarte, California, United States
- USC/ Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Ronald Reagan UCLA Medical Center — Los Angeles, California, United States
- UC Irvine Health — Orange, California, United States
- Colorado Blood Cancer Institute — Denver, Colorado, United States
- Mayo Clinic Florida — Jacksonville, Florida, United States
- Miami Cancer Institute — Miami, Florida, United States
- AdventHealth Orlando — Orlando, Florida, United States
- Memorial Cancer Institute — Pembroke Pines, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Winship Cancer Institute — Atlanta, Georgia, United States
- Northwestern Memorial Hospital/Main Lab — Chicago, Illinois, United States
- The University of Chicago Medical Centre — Chicago, Illinois, United States
- University of Kansas Hospital — Fairway, Kansas, United States
- University of Kentucky Medical Center — Lexington, Kentucky, United States
- Tulane Medical center — New Orleans, Louisiana, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Mayo Clinic Cancer Center Outpatient Pharmacy — Rochester, Minnesota, United States
- MidAmerica Division, Inc., c/o Research Medical Center — Kansas City, Missouri, United States
- SSM Health Saint Louis University Hospital — St Louis, Missouri, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Columbia University Medical Center - Herbert Irving Pavilion — New York, New York, United States
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.