STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance

Recruiting now · Not applicable

Conditions studied: ST Elevation Myocardial Infarction

In brief

The purpose of is study is to investigate whether ischemic postconditioning (iPOST) and intravascular ultrasound-guided (IVUS) percutaneous coronary intervention (PCI) improve the clinical outcome of patients with ST-segment elevation myocardial infarction treated with primary PCI.

Key facts

Study ID

NCT04775914

Run by

Thomas Engstrom

People needed

2500

Starts

2021-04-01

Expected to finish

2031-02-01

Last updated by the study team

2026-03-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Acute onset of chest pain with <12 hours duration
• STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.
• Exclusion Criteria (iPOST2):
• Pre-PCI TIMI flow 0 or 1 Potential pregnancy Inability to provide informed consent Unwillingness to consent Unavoidable to use thrombectomy Spontaneous coronary artery dissection Time from symptoms onset to PPCI > 12 hours Culprit in bypass graft Other reason for not including the patient
• Exclusion Criteria (iSTEMI):
• Potential pregnancy Inability to understand information in order to provide informed consent Unwillingness to consent Spontaneous coronary artery dissection Time from symptoms inset to PPCI > 12 hours Culprit in bypass graft Other reason

Where it is running

• Heart Center, Rigshospitalet — Copenhagen, Capital Region, Denmark (enrolling)

Full record on ClinicalTrials.gov

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