Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV)

Recruiting now

Conditions studied: Arteriovenous Malformations

In brief

Cerebral and medullary arteriovenous malformations (AVMs) lead to arterial and venous networks to communicate pathologically, creating an arteriovenous shunt. The occurrence of intracranial haemorrhage is the most important prognostic factor of AVMs because it is associated with a significant morbidity and mortality. The genetic, molecular and cellular mechanisms that cause vascular malformations of the central nervous system are partially known and the influence of genetic damage on the prognosis of AVMs is poorly known.

Key facts

Study ID

NCT04772963

Run by

Fondation Ophtalmologique Adolphe de Rothschild

People needed

300

Starts

2022-02-17

Expected to finish

2027-03-01

Last updated by the study team

2026-01-22

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient with a vascular malformation of the cerebral or medullary identified on diagnostic imaging (angio-CT, angio-MRI or diagnostic angiography) for which clinical monitoring alone or intervention (endovascular treatment, surgery or radiosurgery) is planned in the centres participating in the research.

You may not qualify if…

• Pregnant, parturient or breastfeeding woman

Where it is running

• HOPITAL FONDATION Adolphe de ROTHSCHILD — Paris, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.