A Single and Multiple Ascending Dose Trial of KT-474 in Healthy Adult Volunteers and Patients With Atopic Dermatitis (AD) or Hidradenitis Suppurativa (HS)
Completed · Phase 1 · Has a placebo group
Conditions studied: Healthy Volunteer, Atopic Dermatitis, Hidradenitis Suppurativa
In brief
KT-474 is an oral heterobifunctional small molecule IRAK4 degrader being developed for the treatment of interleukin-1 receptor (IL-1R)/toll-like receptor (TLR)-driven immune-inflammatory diseases. This first-in-human (FIH) study will characterize the safety, tolerability and the pharmacokinetics/pharmacodynamics (PK/PD) of a single ascending dose and multiple ascending doses of KT-474 in healthy volunteers and patients with atopic dermatitis (AD) or hidradenitis suppurativa (HS). The effects of food on the absorption of KT-474 will also be evaluated in healthy volunteers.
Key facts
- Study ID
- NCT04772885
- Run by
- Kymera Therapeutics, Inc.
- People needed
- 154
- Starts
- 2021-02-23
- Expected to finish
- 2022-10-20
- Last updated by the study team
- 2022-10-24
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
Where it is running
- Medical Dermatology Specialists — Phoenix, Arizona, United States
- Southwest Skin Specialists 32nd St — Phoenix, Arizona, United States
- Southwest Skin Specialists Tatum — Phoenix, Arizona, United States
- Beatrice Keller Clinic — Sun City West, Arizona, United States
- Encore Medical Research, LLC. - Boynton Beach — Boynton Beach, Florida, United States
- Research Centers of America — Hollywood, Florida, United States
- Encore Medical Research, LLC. - Hollywood — Hollywood, Florida, United States
- Encore Medical Research, LLC. - Weston — Weston, Florida, United States
- Dermatology and Skin Cancer Center of Leawood — Leawood, Kansas, United States
- Dermatology and Skin Cancer Center of Overland Park — Overland Park, Kansas, United States
- Dermatology and Skin Cancer Center of Lee's Summit — Lee's Summit, Missouri, United States
- TKL Research — Fair Lawn, New Jersey, United States
- U.S. Dermatology Partners Jollyville — Austin, Texas, United States
- U.S. Dermatology Partners Cedar Park — Cedar Park, Texas, United States
Full record on ClinicalTrials.gov
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