A Study of BGB-11417 in Participants With Myeloid Malignancies
Recruiting now · Phase 1/Phase 2
Conditions studied: Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm
In brief
The study will determine the safety, tolerability, recommended Phase 2 dose (RP2D) and preliminary efficacy of BGB-11417 as monotherapy and in combination with azacitidine in participants with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)or MDS/myeloproliferative neoplasm (MPN) .
Key facts
- Study ID
- NCT04771130
- Run by
- BeOne Medicines
- People needed
- 260
- Starts
- 2021-05-24
- Expected to finish
- 2028-02-08
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The Christie Hospital — Greater Manchester, United Kingdom (enrolling)
- Tampa General Hospital — Tampa, Florida, United States (enrolling)
- Upmc Hillman Cancer Center(Univ of Pittsburgh) — Pittsburgh, Pennsylvania, United States (enrolling)
- Md Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- Concord Repatriation General Hospital — Concord, New South Wales, Australia (enrolling)
- St George Hospital — Kogarah, New South Wales, Australia (enrolling)
- Orange Health Hospital — Orange, New South Wales, Australia (enrolling)
- Gold Coast University Hospital — Southport, Queensland, Australia (enrolling)
- Monash Health — Clayton, Victoria, Australia (enrolling)
- St Vincents Hospital Melbourne — Fitzroy, Victoria, Australia (enrolling)
- Austin Health — Heidelberg, Victoria, Australia (enrolling)
- The Alfred Hospital — Melbourne, Victoria, Australia (enrolling)
- Fiona Stanley Hospital — Murdoch, Western Australia, Australia (enrolling)
- Linear Clinical Research — Nedlands, Western Australia, Australia (enrolling)
- One Clinical Research — Nedlands, Western Australia, Australia (enrolling)
- Peking University Peoples Hospital — Beijing, Beijing Municipality, China (enrolling)
- The First Hospital of Lanzhou University — Lanzhou, Gansu, China (enrolling)
- Guangdong Provincial Peoples Hospital — Guangzhou, Guangdong, China (enrolling)
- Nanfang Hospital, Southern Medical University — Guangzhou, Guangdong, China (enrolling)
- Hospital Universitario Virgen Del Rocio — Seville, Spain (enrolling)
- Hospital Universitari I Politecnic La Fe — Valencia, Spain (enrolling)
- Edinburgh Cancer Centre — Edinburgh, United Kingdom (enrolling)
- Henan Cancer Hospital — Zhengzhou, Henan, China (enrolling)
- Union Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
Full record on ClinicalTrials.gov
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