Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study
Completed · Not applicable
Conditions studied: Atrial Fibrillation, Stroke, Stroke, Cardiovascular, Vascular Cognitive Impairment, Strokes Thrombotic, Stroke, Ischemic
In brief
Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.
Key facts
- Study ID
- NCT04769310
- Run by
- Tulane University
- People needed
- 5
- Starts
- 2021-04-26
- Expected to finish
- 2026-01-27
- Last updated by the study team
- 2026-03-05
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients
- 18 Years and older
- No history of atrial fibrillation
- CHA2DS2VASC score ≥3
- History pf type II diabetes
- History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease
You may not qualify if…
- History of atrial fibrillation
- Patients who had a clinically symptomatic acute stroke within the last 30-days
- Any health-related gadolinium/MRI contraindication (including previous allergic reaction to Gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
- Estimated glomerular filtration rate (eGFR) cutoff in patients with Chronic kidney disease (CKD) where gadolinium cannot be used equals an eGFR <30 ml/min
- Weighing > 300 lbs (as CMR image quality decreases due to increased body mass index)
- Current pregnancy or breastfeeding
- Cognitive impairment preventing the patient from giving an informed consent
Where it is running
- Tulane University Medical Center — New Orleans, Louisiana, United States
Full record on ClinicalTrials.gov
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