Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
Completed
Conditions studied: Atrial Fibrillation, Arrhythmia
In brief
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age. Confirming the regions of epigenetic elements associated with upregulation of the inflammatory genes will help the investigators in identifying target sites for developing future therapeutic interventions. The investigators propose to confirm the monocyte-cell type specific DNA methylation profile of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) and determine the age-related and AF-related changes in DNA methylation and expression of NLRP3 in monocytes. This study will provide insights into the epigenetic regulation of NLRP3 in young and elderly patients, as well as in AF patients vs. controls which will help in devising methods of modulating NLRP3 expression and decreasing cardiac fibrosis progression.
Key facts
- Study ID
- NCT04766814
- Run by
- Tulane University
- People needed
- 29
- Starts
- 2021-10-22
- Expected to finish
- 2024-02-16
- Last updated by the study team
- 2024-04-25
Who can join
Age: 20 and older, up to 80. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Subjects aged 18 or above,
- Control Group scheduled for routine annual health check-up and healthy blood donors without any documentation of cardiovascular disease or other serious immune-related illnesses, such as diabetes, hypertension, autoimmune arthritis etc
- healthy women subjects between the ages of 50-80 years
- healthy women subjects between the ages of 20-30 years.
- Study Patients -women between the ages of 50 - 80 years diagnosed with AF as evidenced by rhythm strips or written documentation.
You may not qualify if…
- Previous left atrial ablation or any type of valvular surgery
- Patients who are taking medications like Ibuprofen, Toradol, Naproxen and other common over-the -counter NSAIDs.
- Women who are pregnant
- Terminally ill patients
Where it is running
- Tulane University Medical Center — New Orleans, Louisiana, United States
Full record on ClinicalTrials.gov
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