Turmeric and Exercise-Induced Muscle Damage and Oxinflammation

Completed · Not applicable · Has a placebo group

Conditions studied: Muscular Injury

In brief

The purpose of this study is to measure the effect of using a turmeric-based supplement for 2-weeks on muscle damage and soreness that occur in the body after 90-minutes of exercise. Participants will first come to the human performance lab (HPL) for orientation and pre-study fitness tests including muscular fitness and body composition. Participants will be randomized to turmeric or placebo groups, and take 2 tablets of the supplements each day for the first two weeks. Participants will report back to the HPL on a Monday to engage in weight lifting and calisthenics for 90 minutes. Fitness tests (vertical jump, bench press, leg-back lift for strength, 30-second cycling sprint test) and blood samples will be given and collected before and after this exercise session. Participants will then come back to the HPL each morning, Tuesday through Friday, in the early morning to provide blood samples and retake the fitness tests. This study will entail seven HPL visits over a 3-week period.

Key facts

Study ID

NCT04765527

Run by

Appalachian State University

People needed

53

Starts

2020-12-15

Expected to finish

2021-06-15

Last updated by the study team

2021-06-21

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female, ages 18-50 years.
• Non-smoker.
• Body mass index less than 35 kg/m2 (below moderate or severe obesity).
• Not engaged in regular resistance training (less than 3 sessions per week).
• Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, protein supplements, herbs, and medications that influence inflammation and immune function (especially Advil, Motrin, aspirin, and similar anti-inflammatory drugs) for the duration of the study. (You will review your supplement and medication use with the Research Manager during orientation).
• Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
• Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.

You may not qualify if…

• Inability to comply with study requirements.
• Engaged in regular resistance training (3 or more sessions per week, on average).
• Body weight below 110 pounds.
• Pregnant or breastfeeding.
• Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
• Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
• History of allergic reactions to turmeric, devil's claw, boswellia extract, or ginger extract.

Where it is running

• Appalachian State University Human Performance Lab, North Carolina Research Campus — Kannapolis, North Carolina, United States

Full record on ClinicalTrials.gov

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