Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Recruiting now · Phase 2

Conditions studied: Mild Cognitive Impairment

In brief

The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

Key facts

Study ID

NCT04765137

Run by

Johns Hopkins University

People needed

20

Starts

2021-05-21

Expected to finish

2027-12-31

Last updated by the study team

2026-07-13

Who can join

Age: 60 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Taking a statin currently or have taken a statin in the last 6 months.
• Contraindications to taking a statin.
• Transplant patient taking cyclosporine.
• Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
• Diagnosis of dementia by history.
• Current diagnosis of substance abuse.
• History of stroke or myocardial infarction in past 6 months.
• History of HIV.

Where it is running

• Johns Hopkins University, Bayview Medical Center — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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