CMR Versus CT in Coronary Artery Disease

Recruiting now

Conditions studied: Coronary Artery Disease

In brief

CONCORD is a prospective observational study evaluating the diagnostic accuracy of cardiovascular magnetic resonance (CMR) and computed tomography with fractional flow reserve (CT-FFR) in patients with suspected coronary artery disease, using invasive fractional flow reserve (FFR) as the reference standard.

Key facts

Study ID

NCT04761991

Run by

University of Leicester

People needed

300

Starts

2020-11-05

Expected to finish

2025-11-30

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged ≥18 years
• Referred for invasive coronary angiography for investigation of chest pain

You may not qualify if…

• Recent acute coronary syndrome (< 6 months)
• Previous coronary artery bypass grafting
• Severe claustrophobia
• Absolute contraindications to CMR - those with MR conditional or safe devices will be included
• Second-/third-degree atrioventricular block
• Severe chronic obstructive pulmonary disease
• Moderate-severe asthma
• Estimated glomerular filtration rate <30 ml/min/1.73m2
• Women who are pregnant, breast-feeding or of child-bearing potential( premenopausal women)
• Contraindication to iodinated contrast
• Participation in a research study involving an investigational product in the past 12 weeks

Where it is running

• Glenfield Hospital — Leicester, Leics, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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