Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum

Recruiting now

Conditions studied: Emphysema

In brief

The hypothesis is that in patients with emphysema, a high MMP12 sputum and/or blood level correlates with airspace enlargement and with increased sputum Th2 immune biomarkers.

Key facts

Study ID

NCT04761393

Run by

McMaster University

People needed

45

Starts

2022-11-29

Expected to finish

2025-01-01

Last updated by the study team

2024-11-20

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Any potential subject who meets any of the following criteria will be excluded from participating in the study:
• Patients with other non-COPD airway diseases
• Patients with very severe COPD (FEV1<30% predicted)
• Patients with an intercurrent exacerbation
• Patients with life expectancy less than 3 months
• Pregnant or breastfeeding
• Undergoing immunomodulatory or biologic treatment
• Use of systemic steroids in the last month
• Hospitalization in the last 12 months due to exacerbation
• Known cardiovascular comorbidity under treatment or with hospitalizations of this cause in the last year
• That they cannot perform spirometry
• Active malignancy
• Realization of lung surgery during the study period
• History of alcohol and drug abuse that prevents compliance with follow-up
• History of bronchial thermoplasty
• Participating in another study concomitantly
• MRI Related: patients who have implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, artificial limb, metallic fragments of foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants).

Where it is running

• Firestone Institute for Respiratory Health, St. Joseph's Healthcare — Hamilton, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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