Genome-based Management of Patients in Precision Medicine (Ge-Med) Towards a Genomic Health Program

Recruiting now · Not applicable

Conditions studied: Rare Diseases, Genetic Predisposition to Disease

In brief

The GE-MED APPROACH project will enroll patients (n = appr. 12.000) with unclear molecular cause of the disease, suspected genetic cause of the disease without detailed molecular analysis like Whole Exome Sequencing (WES). The novelty of this study is to integrate genomic health concepts into immediate clinical care. To achieve these goals, a novel structure for the Triple P (3P) concept of personalized medicine (Personalized, Predictive, Preventive) integrated into a well-established health care system and associated with novel decentralized Disease Analysing Task Forces (DATF) will be implemented. The overall goal of this study is to implement, for the first time, Whole Genome Sequencing (WGS) analysis as a first line diagnostic test for all clinical indications such as Rare Disease (RD )and familial cancer syndromes.

Key facts

Study ID

NCT04760522

Run by

University Hospital Tuebingen

People needed

12000

Starts

2021-06-01

Expected to finish

2027-07-01

Last updated by the study team

2023-11-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unclear molecular cause of the disease
• Suspected genetic cause of the disease

You may not qualify if…

• Missing informed consent of the patient and if applicable the legal representative
• Previously performed WES or panel analysis

Where it is running

• University Hospital Tübingen — Tübingen, Germany (enrolling)

Full record on ClinicalTrials.gov

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