Direct Measurement of Motor Cortical Responses to tDCS

Completed

Conditions studied: Parkinson Disease

In brief

Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. The investigators hypothesize that by studying the effects of tDCS in subjects performing a motor task, the brain signals mediating improvements in motor control will be identified. The investigators will use both noninvasive and invasive methods to explore this hypothesis. The investigators expect this combined approach to broaden understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in these populations.

Key facts

Study ID

NCT04759898

Run by

Medical University of South Carolina

People needed

20

Starts

2021-01-01

Expected to finish

2025-01-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Previous consent to be contacted regarding potential participation in a research study at Medical University of South Carolina

You may not qualify if…

• Subjects unable to actively participate in the consent process physically and/or cognitively
• Pregnancy
• Presence of scalp injury or disease
• Prior history of seizures
• Metal implants in head or neck
• Prior intracranial surgery
• Prior brain radiotherapy
• Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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