Insulin and Muscle Fat Metabolism

Stopped early · Not applicable

Conditions studied: Overweight and Obesity, Insulin Resistance, Metabolic Disease, Mitochondrial Metabolism, Sedentary Lifestyle

In brief

Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans. We will test the hypothesis that 4-hours of mild hyperinsulinemia will result in significant muscle lipid accumulation and that such effects will be similar in lean and overweight/obese humans.

Key facts

Study ID

NCT04759872

Run by

Oregon State University

People needed

9

Starts

2021-02-22

Expected to finish

2022-06-07

Last updated by the study team

2022-06-10

Who can join

Age: 30 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 30-55 years
• Body mass index (BMI) 18-45 kg/m2
• Sedentary (<1 hour of planned exercise per week)

You may not qualify if…

• Regular exercise (>1 hour of planned exercise per week)
• Smoking, tobacco or nicotine use within the last 1-year
• Fasting glucose >126mg/dL
• Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
• Chronic metabolic or cardiovascular health conditions
• Pregnant, nursing, irregular menses or post-menopausal
• Lidocaine allergy
• Certain medications
• Diminished capacity for consent

Where it is running

• Oregon State University — Corvallis, Oregon, United States

Full record on ClinicalTrials.gov

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