Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention.

Completed · Not applicable

Conditions studied: Diabetes

In brief

This study seeks to establish the efficacy of identifying weight loss nonresponders early in a Diabetes Prevention Program (DPP) intervention in 20 community settings (primarily churches and community centers) and providing them with individual-level, enhanced treatment through telephone contacts and access to additional resources. Additionally, potential mediators and moderators of the relationship between intervention status and weight loss response at 6 months in both nonresponders and responders will be examined and a cost-effectiveness analysis to evaluate the cost of the intervention will be conducted. This study addresses key gaps in the literature about the weight loss effects of identifying nonresponders early and characterizing individuals who need more intense personalized strategies. The investigators hypothesize that changes between baseline and 3 months will be more pronounced among the nonresponders in the intervention group compared to the nonresponders in the active control group.

Key facts

Study ID

NCT04757519

Run by

Lovoria Williams

People needed

403

Starts

2021-02-18

Expected to finish

2026-04-17

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• self-described as Black
• non-diabetic
• body mass index (BMI) equal to or greater than 25
• CDC diabetes risk assessment greater than or equal to 5 or diabetes pre-diagnosis or history of gestational diabetes
• live within driving distance of participating church/site

You may not qualify if…

• diagnosed Type 1 or 2 diabetes
• pregnant or planning to become pregnant during study period
• contraindications to moderate physical activity
• serious medical condition that contradicts weight loss
• not Black or African American

Where it is running

• First Corinthian Baptist Church — Frankfort, Kentucky, United States
• Heavenly Outpour — Frankfort, Kentucky, United States
• Consolidated Baptist Church — Lexington, Kentucky, United States
• Historic St. Paul AME Church — Lexington, Kentucky, United States
• First African Baptist Church — Lexington, Kentucky, United States
• Pilgrim Baptist Church — Lexington, Kentucky, United States
• Shiloh Baptist Church — Lexington, Kentucky, United States
• Redeemed Christian Church of God — Lexington, Kentucky, United States
• First Baptist Church Brackstown — Lexington, Kentucky, United States
• Lima Drive Seventh Day Adventist Church — Lexington, Kentucky, United States
• Kingdom Fellowship — Louisville, Kentucky, United States
• Bates Memorial Baptist Church — Louisville, Kentucky, United States
• St. Stephen Baptist Church — Louisville, Kentucky, United States
• Greater Gaililee CDC — Louisville, Kentucky, United States
• Historic Calvary MBC — Louisville, Kentucky, United States
• Spirit Filled New Life Church — Louisville, Kentucky, United States
• Forest Baptist Church — Louisville, Kentucky, United States
• Burnett Ave BC — Louisville, Kentucky, United States
• Marnel C. Moorman Family Life Center — Shelbyville, Kentucky, United States
• New Mt. Zion Baptist Church — Shelbyville, Kentucky, United States
• First Baptist Winchester — Winchester, Kentucky, United States

Full record on ClinicalTrials.gov

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