The Precision CAD Trial
Running, not enrolling · Not applicable
Conditions studied: Coronary Artery Disease
In brief
People with Coronary Artery Disease (CAD) have narrow or blocked arteries that supply blood to the heart. Reduced blood flow to the heart muscle from CAD can cause chest pain or aching, especially with exercise or activity. CAD can lead to weakening of the heart muscle or heart failure, and a higher risk of heart attack or death. Certain proteins in the blood, known as biomarkers, can be found in people with CAD. Higher levels of these biomarkers are associated with a greater risk of complications from CAD. The purpose of this study is to see if a customized treatment based on biomarkers will reduce the biomarker levels and lead to lower risk of complications from CAD.
Key facts
- Study ID
- NCT04755413
- Run by
- Emory University
- People needed
- 276
- Starts
- 2022-10-19
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2025-11-21
Who can join
Age: 21 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Individuals aged 21-90 years with stable CAD.
- Patients with any amount of atherosclerosis via coronary angiogram or coronary computed tomography angiography (CCTA).
- Patients undergoing revascularization therapy or recent acute coronary syndrome (ACS) will be eligible for recruitment and will be recruited at least 4 weeks after admission for an ACS or percutaneous intervention and 3 months after coronary bypass graft surgery.
- Patients with CAC levels ≥ 400
You may not qualify if…
- Planned revascularization,
- New York Heart Association class III or IV heart failure symptoms,
- LVEF <40%,
- eGFR<45,
- Pregnancy, congenital heart disease, severe symptomatic valvular heart disease, active malignancy and cardiac transplant.
Where it is running
- Emory Johns Creek Hospiatl — Atlanta, Georgia, United States
- Emory University Hospital Midtown — Atlanta, Georgia, United States
- Emory University Hospital — Atlanta, Georgia, United States
- The Emory Clinic — Atlanta, Georgia, United States
- Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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