Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Recruiting now · Not applicable

Conditions studied: Disorder, Heart, Postoperative, Cardiac Surgery

In brief

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

Key facts

Study ID

NCT04754022

Run by

Unity Health Toronto

People needed

1440

Starts

2021-11-01

Expected to finish

2026-06-01

Last updated by the study team

2024-11-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥18 and ≤65 years of age
• Planned cardiac surgery using cardiopulmonary bypass
• Informed consent obtained
• Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

You may not qualify if…

• Patients who refuse participation
• Patients who are unable to receive or who refuse blood products
• Patients who are involved in a preoperative autologous pre-donation program
• Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
• Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)

Where it is running

• Centre hospitalier de l'Université de Montréal — Montreal, Quebec, Canada (enrolling)
• Maine Medical Center — Portland, Maine, United States (enrolling)
• The Cooper Health System — Camden, New Jersey, United States (enrolling)
• Montreal Heart Institute — Montreal, Quebec, Canada (enrolling)
• Royal Prince Alfred hospital — Camperdown, New South Wales, Australia (enrolling)
• Prince of Wales Hospital — Randwick, New South Wales, Australia (enrolling)
• Westmead Hospital — Westmead, New South Wales, Australia (enrolling)
• Gold Coast University Hospital — Southport, Queensland, Australia (enrolling)
• Flinders Medical Centre — Bedford Park, South Australia, Australia (enrolling)
• Royal Adelaide Hospital — Adelaide, Adelaide, Australia (enrolling)
• St Vincent's Hospital Melbourne — Fitzroy, Victoria, Australia (enrolling)
• Austin Health — Heidelberg, Victoria, Australia (enrolling)
• Royal Melbourne Hospital — Melbourne, Australia (enrolling)
• Alfred Hospital — Prahran, Australia (enrolling)
• University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)
• Interior Health Kelowna General Hospital — Kelowna, British Columbia, Canada (enrolling)
• Vancouver General Hospital — Vancouver, British Columbia, Canada (enrolling)
• Saint John Regional Hospitall — Saint John, New Brunswick, Canada (enrolling)
• Health Sciences North Research Institute — Greater Sudbury, Ontario, Canada (enrolling)
• Hamilton Health Sciences Centre / Hamilton General Hospital — Hamilton, Ontario, Canada (enrolling)
• Monash Health — Clayton, Victoria, Australia (enrolling)
• Sunnybrook Health Sciences Center — Toronto, Ontario, Canada (enrolling)
• St. Michael's Hospital, Unity Health Toronto — Toronto, Ontario, Canada (enrolling)
• Toronto General Hospital — Toronto, Ontario, Canada (enrolling)
• Jewish General Hospital — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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