Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Recruiting now

Conditions studied: Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma

In brief

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Key facts

Study ID

NCT04753996

Run by

Mayo Clinic

People needed

300

Starts

2021-03-08

Expected to finish

2035-01-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• PSC
• Patients diagnosed with PSC between the age of 18 and 85.
• The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
• Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.
• Controls
• Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85.

You may not qualify if…

• Patients unable to provide inform consent.
• Prisoners and institutionalized individuals.
• PSC with orthotopic liver transplantation
• History of Roux En Y procedure

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.