ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)
Stopped early · Phase 2
Conditions studied: Esophageal Cancer, Esophagogastric Junction Cancer
In brief
This study will investigate the efficacy of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and tumor antigen status and whose esophageal or esophagogastric junction (EGJ) cancer expresses the MAGE-A4 protein.
Key facts
- Study ID
- NCT04752358
- Run by
- Adaptimmune
- People needed
- 3
- Starts
- 2021-09-15
- Expected to finish
- 2023-12-15
- Last updated by the study team
- 2024-09-04
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope National Medical Center — Duarte, California, United States
- University of Chicago Medicine — Chicago, Illinois, United States
- Washington University School of Medicine- Siteman Cancer Center — St Louis, Missouri, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Providence Cancer Institute Franz Clinic — Portland, Oregon, United States
- University Of Texas, MD Anderson Cancer Center — Houston, Texas, United States
- University Of Wisconsin Clinical Science Center — Madison, Wisconsin, United States
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada
- McGill University Health Centre Glen Site — Montreal, Quebec, Canada
- Hospital Universitari Vall d'Hebron — la Vall d'Hebron, Barcelona, Spain
- Hospital Universitario 12 de Octubre — Córdoba, Madrid, Spain
- Hospital Clinico Universitario de Valencia — Ibáñez, Valencia, Spain
- Hospital Fundacion Jimenez Diaz — Madrid, Spain
- Hospital Universitario Madrid Sanchinarro (CIOCC) — Madrid, Spain
- Clinica Universidad de Navarra — Navarro, Spain
- Hospital Universitario Virgen del Rocio — Seville, Spain
Full record on ClinicalTrials.gov
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