Impaired Glucose Tolerance and Cognition in MS

Stopped early

Conditions studied: Multiple Sclerosis

In brief

This is a pilot study to compare cognitive performance in two groups of subjects with multiple sclerosis; those with normal glucose tolerance and those with impaired glucose tolerance. The study consists of a 2 hour oral glucose tolerance test, patient reported outcomes, a series of cognitive functioning tests, and outpatient physical assessment using a pedometer.

Key facts

Study ID

NCT04748302

Run by

University of Virginia

People needed

7

Starts

2020-01-06

Expected to finish

2020-04-01

Last updated by the study team

2021-02-10

Who can join

Age: 18 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to provide informed consent
• Diagnosis of Clinically Isolated Syndrome (CIS) or Relapsing Remitting Multiple Sclerosis (RRMS) confirmed by McDonald 2010 criteria
• EDSS < 6.5 at time of visit

You may not qualify if…

• Diabetes type I or II
• use of glucose regulating medications
• fasting blood glucose of > 126 mg/dl
• known cardiac or respiratory disease
• morbid obesity (BMI >40)
• steroid exposure within 4 weeks of enrollment
• pregnancy or current use of hormone replacement therapy

Where it is running

• University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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