Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol

Completed

Conditions studied: Gout

In brief

This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.

Key facts

Study ID

NCT04746989

Run by

Brigham and Women's Hospital

People needed

294878

Starts

2021-02-01

Expected to finish

2023-12-31

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 1. No prior use of urate-lowering agents, including probenecid and allopurinol anytime prior to cohort entry date
• 2. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date

You may not qualify if…

• 1. Prior history of dementia measured anytime prior to cohort entry date
• 2. No prior history of gout recorded in the 365 days prior to cohort entry date
• 3. Prior history of nursing home admission in the 365 days prior to the cohort entry date

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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