Study of AZD2811 + Durvalumab in ES-SCLC
Running, not enrolling · Phase 2
Conditions studied: Small-Cell Lung Cancer
In brief
A Phase II Multicenter, Open-Label, Single Arm Study to Determine the Efficacy, Safety and Tolerability of AZD2811 and Durvalumab Combination as Maintenance Therapy After Induction with Platinum-Based Chemotherapy Combined with Durvalumab, for the First-Line Treatment of Patients with Extensive Stage Small-Cell Lung Cancer.
Key facts
- Study ID
- NCT04745689
- Run by
- AstraZeneca
- People needed
- 31
- Starts
- 2021-02-23
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Documented evidence of extensive stage SCLC (ES-SCLC)
- Participants must be considered suitable to receive an induction platinum-based chemotherapy regimen, combined with durvalumab, as first-line treatment for ES-SCLC
- No prior exposure to immune-mediated therapy
- Life expectancy ≥12 weeks at Day 1.
- ECOG 0 or 1 at enrolment.
You may not qualify if…
- Any history of radiotherapy to the chest prior to systemic therapy or planned consolidation chest radiation therapy
- Has a paraneoplastic syndrome (PNS) of autoimmune nature, requiring systemic treatment (systemic steroids or immunosuppressive agents) or has a clinical symptomatology suggesting worsening of PNS
- Active infection including tuberculosis, HIV, hepatitis B and C
- Active or prior documented autoimmune or inflammatory disorders
- Uncontrolled intercurrent illness, including but not limited to interstitial lung disease.
Where it is running
- Research Site — Grand Rapids, Michigan, United States
- Research Site — Bydgoszcz, Poland
- Research Site — Olsztyn, Poland
- Research Site — Poznan, Poland
- Research Site — Cheongju-si, South Korea
- Research Site — Jinju, South Korea
- Research Site — Seoul, South Korea
- Research Site — Seoul, South Korea
- Research Site — Seoul, South Korea
- Research Site — Seoul, South Korea
- Research Site — Seville, Spain
- Research Site — Valencia, Spain
Full record on ClinicalTrials.gov
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