HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

Recruiting now · Not applicable

Conditions studied: Hip Fractures, Myocardial Injury

In brief

The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in reducing death at 90 days after randomization. The trial will also assess secondary outcomes at 90 days after randomization: inability to independently walk 3 metres, time to first mobilization (first standing and first full weight bear), composite and individual assessment of major complications (e.g., mortality, non-fatal myocardial infarction, acute congestive heart failure, and stroke), delirium, length of stay, pain, and quality of life.

Key facts

Study ID

NCT04743765

Run by

Population Health Research Institute

People needed

1100

Starts

2021-11-22

Expected to finish

2027-05-31

Last updated by the study team

2025-10-01

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥45 years;
• diagnosis of hip fracture during working hours with a low-energy mechanism requiring surgery;
• troponin elevation ( at least one troponin measurement above the upper limit of normal occurring from the time of hip fracture to the time of randomization); and
• informed consent.

You may not qualify if…

• taking a therapeutic dose of an anticoagulant for which no reversing agent is available and the anesthesiologist or surgeon believe surgery within 6 hours of eligibility criteria met would not be safe;
• patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT);
• patients with peri-prosthetic fracture, open fracture or bilateral fractures;
• patients requiring an emergency surgery for another reason (e.g., subdural hematoma);
• patients with acute myocardial infarction deemed to be clinically unstable, with a mechanical complication (i.e., acute papillary muscle rupture, ventricular septal defect), ST elevation myocardial infarction, or cardiogenic shock;
• patients refusing consent; or
• patients previously enrolled in HIP ATTACK-2.

Where it is running

• The Regents of the University of California — Davis, California, United States (enrolling)
• Yale New Haven Hospital — New Haven, Connecticut, United States (enrolling)
• Emory University at Grady Memorial Hospital — Atlanta, Georgia, United States (enrolling)
• University of Maryland — Baltimore, Maryland, United States (enrolling)
• Sinai Hospital of Baltimore — Baltimore, Maryland, United States (enrolling)
• Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
• Lahey Hospital and Medical Center — Burlington, Massachusetts, United States (enrolling)
• University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Bryan Medical Center — Lincoln, Nebraska, United States (enrolling)
• University Medical Center of Southern Nevada — Las Vegas, Nevada, United States (enrolling)
• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States (enrolling)
• Montefiore Medical Center — The Bronx, New York, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• Oregon Health and Science University — Portland, Oregon, United States (enrolling)
• St. Luke's University Health Network — Bethlehem, Pennsylvania, United States (enrolling)
• The University of Texas Health Science Center at Houston — Houston, Texas, United States (enrolling)
• University of Wisconsin — Madison, Wisconsin, United States (enrolling)
• The John Hunter Hospital — New Lambton Heights, New South Wales, Australia (enrolling)
• Cliniques Universitaires Saint Luc - University Catholic of Louvain — Woluwe-Saint-Lambert, Brussels Capital, Belgium (enrolling)
• University of São Paulo — São Paulo, São Paulo, Brazil (enrolling)
• University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)
• St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (enrolling)
• Juravinski Hospital — Hamilton, Ontario, Canada (enrolling)
• Chandler Regional Medical Center — Chandler, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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