Food and Circadian Timing
Recruiting now · Not applicable
Conditions studied: Diet, High-Fat, Circadian Rhythm
In brief
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.
Key facts
- Study ID
- NCT04743271
- Run by
- Oregon Health and Science University
- People needed
- 14
- Starts
- 2022-04-01
- Expected to finish
- 2026-03-31
- Last updated by the study team
- 2025-11-10
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy, lean men and women
You may not qualify if…
- Major dietary restrictions (such as entirely dairy-free and/or meat-free diets)
- A body mass index (BMI) of 18.5< [BMI] < 24.9 kg/m\^2 and a waist circumference <94/80cm
- Currently psychiatrically/psychologically unsuitable for participation
- Drug/alcohol use, including smoking
- Medication/drug use, including prescribed and over-the-counter medications
- History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.
- Traveled across more than 1 time zone during the 3 months prior to the study
- Currently consuming a habitual high-fat diet
- Chronobiologic and sleep disorders
- Diseases of the Cardiovascular System
- Metabolic Syndrome; Two or more of these factors will be excluded from the study:
- HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women;
- systolic blood pressure>135 mmHg or diastolic blood pressure>85 mmHg;
- Fasting blood glucose ≥ 100 mg/dL;
- Triglycerides ≥ 150 mg/dL.
- Pre-Diabetes/Diabetes
- Hypertension
- Disorders of the Respiratory System
- Disorders of the Kidney and Urinary Tract
- Infectious Diseases
- Disorders of the Gastrointestinal System
- Disorders of the Immune System
- Disorders of the Hematopoietic System
- Neoplastic Diseases
- Endocrine and Metabolic Diseases
Where it is running
- Oregon Health & Science University — Portland, Oregon, United States (enrolling)
Full record on ClinicalTrials.gov
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