AMBulatory UltraSound for Heart Failure Management
Recruiting now · Not applicable
Conditions studied: Heart Failure
In brief
AMBUSH study is a multicenter randomized, controlled, open-label clinical trial (PROBE (Prospective Randomized Open Blinded End-point) type). The main objective of AMBUSH study is to assess the effect of therapeutic management guided by pulmonary ultrasound and the assessment of the inferior vena cava in patients with heart failure seen in an ambulatory (outpatient) setting on a mixed clinical-biological endpoint (including variations of natriuretic peptides - NtProBNP) at 30 days.
Key facts
- Study ID
- NCT04741711
- Run by
- Central Hospital, Nancy, France
- People needed
- 182
- Starts
- 2023-05-15
- Expected to finish
- 2027-06-15
- Last updated by the study team
- 2023-05-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female aged 18 and over
- Heart failure (regardless of left ventricular ejection fraction)
- Diagnosis of heart failure established more than 3 months ago
- Absence of significant clinical signs of congestion on clinical examination (absence of crackles and lower limbs oedema greater than perimalleolar oedema)
- Affiliation to social security
- Receiving complete information about research organization and signed informed consent.
You may not qualify if…
- Natriuretic peptides result, carried out during the previous 30 days, available at the inclusion consultation
- Pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis.
- Suspicion of cardiac amyloidosis or proven amyloidosis,
- Patient with severe primary heart valve disease
- Pregnant woman, parturient or nursing mother
- Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
- Person deprived of liberty by a judicial or administrative decision,
- Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.
Where it is running
- CHRU de Nancy — Vandœuvre-lès-Nancy, France (enrolling)
- CHU de Besançon — Besançon, France
- CH de Mulhouse — Mulhouse, France
- CHRU de Reims — Reims, France
- CHR de Metz — Thionville, France
Full record on ClinicalTrials.gov
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