Microbiome Individuality and Stability Over Time
Completed · Not applicable
Conditions studied: Diet
In brief
Microbial derived uremic solutes (p-cresol sulfate, indoxyl sulfate, and phenylacetylglutamine) are present in blood and excreted into the urine. Uremic solutes have high inter-individual variability of unclear etiology, that the investigators hypothesize is due to intestinal microbiome variation and/or dietary variation between people. In this study, the investigators will collect baseline samples on participant's habitual diet. The investigators will then administer a homogenous diet to all participants for 7 days and examine levels of uremic solutes in the urine via 24-hour urine collection during this period. In parallel, the investigators will monitor microbiome composition. The investigators predict that during the period subjects are consuming the same, homogenous diet, their excretion of uremic solutes (p-cresol sulfate, indoxyl sulfate, and phenylacetylglutamine) into the urine will have less inter-individual variation.
Key facts
- Study ID
- NCT04740684
- Run by
- Stanford University
- People needed
- 21
- Starts
- 2018-08-06
- Expected to finish
- 2019-02-11
- Last updated by the study team
- 2021-05-07
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy individuals
You may not qualify if…
- pregnancy
- diabetes
- gastrointestinal disease
- use of medications thought by the investigators to have a significant effect on the microbiome
Where it is running
- Stanford University — Stanford, California, United States
Full record on ClinicalTrials.gov
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