Ketone Supplements and Substrate Oxidation and Physical Performance
Status unconfirmed · Not applicable
Conditions studied: Ketosis, Glucose Metabolism
In brief
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults. Following a 48-hr muscle glycogen normalization period, volunteers will consume either an isocaloric KE+CHO (KE: 573 mg KE/kg body mass, CHO: 110 g) or isocaloric CHO drink and complete 90-min of metabolically-matched, load carriage (\~30% body mass) steady-state aerobic (\~60 ± 5 % of VO2peak) exercise on a treadmill. Glucose tracers will be used to assess glucose turnover, and contribution to exogenous and plasma glucose oxidation. Serial blood draws will be collected during each trial to assess endocrine and circulating substrate responses. After steady-state exercise volunteers will complete a time to exhaustion (TTE) physical performance tests at 85% VO2peak on a treadmill. Volunteers will then be provided with food for the remainder of the day. Following a 10-hr overnight fast, volunteers will return to the laboratory and consume the same supplement (KE+CHO or CHO) as they did the previous day. Volunteers will then perform a 4-mile load carriage time trial on a treadmill. Following a minimum 7-day washout period, volunteers will return to the laboratory to complete the second arm of the study. The primary risks associated with this study include those associated with exercise, blood draws, and gastrointestinal discomfort from the KE+CHO supplement.
Key facts
- Study ID
- NCT04737694
- Run by
- United States Army Research Institute of Environmental Medicine
- People needed
- 15
- Starts
- 2020-11-01
- Expected to finish
- 2022-09-01
- Last updated by the study team
- 2021-10-14
Who can join
Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women aged 18 - 39 years
- Body mass index (BMI) < 30 kg/m2
- Routinely participate in aerobic and/or resistance exercise at least 2 days per week
- Refrain from the use of caffeine, alcohol, dietary supplements, and nicotine while consuming study diets
- Supervisor approval to participate for active duty military and federal civilian employees working within the US Army Natick Soldier Systems Center
You may not qualify if…
- Metabolic or cardiovascular abnormalities, gastrointestinal disorders (i.e., kidney disease, diabetes, cardiovascular disease, etc.)
- Disease or medication (i.e., diabetes medications, statins, corticosteroids, etc) that affects macronutrient utilization and/or the ability to participate in strenuous exercise
- Allergies or intolerance to foods (including but not limited to lactose intolerance/milk allergy) to be utilized in the study or vegetarian practices
- Present condition of alcoholism, anabolic steroids, or other substance abuse issues
- Musculoskeletal injuries that compromise the ability to exercise
- Not willing to avoid non-study exercise and foods during each of the 3 day testing periods
- Blood donation within 8 weeks of beginning the study
- Pregnant or breast feeding
Where it is running
- USARIEM — Natick, Massachusetts, United States
Full record on ClinicalTrials.gov
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