The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

Recruiting now · Not applicable

Conditions studied: Feeding Patterns, Sleep, Glucose Intolerance

In brief

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

Key facts

Study ID

NCT04737200

Run by

Massachusetts General Hospital

People needed

30

Starts

2022-02-08

Expected to finish

2027-03-31

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult male or non-pregnant female volunteers (age 18+)
• Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for >48 hours
• Able and willing to give consent and comply with study procedures

You may not qualify if…

• Blind, deaf or unable to speak English
• Women who are pregnant or nursing
• Contraindications to safe use enteral nutrition, including gastrointestinal obstruction
• Personal history of intestinal malabsorption, gallbladder disease or pancreatitis
• Dietary restrictions precluding enteral feeds
• Renal and liver failure requiring dialysis or Child-Pugh score > 7
• Severe deficit due to structural or anoxic brain damage
• With skin condition that precludes wearing sensors

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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