Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury

Recruiting now

Conditions studied: Brachial Plexus Injury

In brief

The purpose of this study is to see how much pain intensity is affected by high frequency spinal cord stimulation therapy in individuals with serious brachial plexus injury.

Key facts

Study ID

NCT04733599

Run by

Mayo Clinic

People needed

20

Starts

2021-02-01

Expected to finish

2026-12-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years old
• Neuropathic pain of the upper limb ≥ 3 months following brachial plexus avulsion injury.
• Patients must be planned to undergo implantation of high-frequency spinal cord stimulation for the treatment of chronic neuropathic pain due to brachial plexus avulsion injury.

You may not qualify if…

• Pain that is non-neuropathic as defined by DN4 score <4.
• Pregnant at the time of consideration for implant or planning to become pregnant during the study duration.
• Active substance use disorder of any kind.
• Active tobacco use.
• Use of moderate or high dose opioid medication (oral morphine equivalents >100 mg daily).
• Active, untreated major psychiatric disorder that might interfere with subject's ability to participate.
• Involvement in active litigation related to injury.
• Patient has not undergone conservative medical management for at least 3 months (including physical and/or occupational therapy and at least one trial of neuropathic pain medication).

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States (enrolling)
• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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