Heat Therapy and Muscle Function Study

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Exercise Intolerance, Aging, Heat Therapy, High Intensity Interval Training

In brief

Exercise tolerance decreases with age and a sedentary lifestyle. Muscle critical power (CP), is a sensitive measure of exercise tolerance that is more even more relevant to and predictive of endurance performance than VO2max. While recent evidence indicates that CP and muscle function decrease with aging, the cause of this decrease in CP and the best way to mitigate the decrease in CP are unknown. This study will: 1. Measure knee extensor CP in young and old individuals and determine the extent to which changes in muscle oxygen delivery (e.g. resistance artery function, maximum exercise blood flow), muscle mass and composition (e.g. whole-muscle size, muscle fiber cross-sectional area) and mitochondrial oxygen consumption (e.g. maximal coupled respiration of permeabilized fibers biopsied from the knee extensors) contribute to the decrease in CP with age. 2. Examine the effectiveness of two different therapies (1. High Intensity Interval Training, HIIT and 2. Muscle Heat Therapy) at improving muscle function and critical power in young and older adults. 3. Examine the impact of muscle disuse (2 weeks of leg immobilization), a potential contributor to the decrease in muscle function with aging, on muscle function and critical power and determine if heat therapy is an effective means of minimizing the impact of disuse on muscle function and critical power.

Key facts

Study ID

NCT04733287

Run by

Brigham Young University

People needed

148

Starts

2021-04-01

Expected to finish

2024-12-31

Last updated by the study team

2021-02-02

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-95 years of age
• Currently no cardiovascular or metabolic disease (e.g. heart failure, diabetes)
• ability to perform knee extension exercise

You may not qualify if…

• Pregnant
• Current cardiovascular or metabolic disease (e.g. heart failure, diabetes)
• participating in exercise training within the last 6 months
• inability to perform knee extension exercise

Where it is running

• Brigham Young University — Provo, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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