Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection

Running, not enrolling

Conditions studied: Kidney Transplant Rejection

In brief

Global, non-randomized, observational study for the validation of Verici Dx genomic tests to predict risk of kidney clinical and subclinical acute rejection, and chronic allograft damage or interstitial fibrosis / tubular atrophy by correlating peripheral blood gene expression profiles with graft injury (e.g. cellular / antibody-mediated), rejection and death censored graft loss.

Key facts

Study ID

NCT04727788

Run by

Verici Dx

People needed

550

Starts

2021-03-21

Expected to finish

2025-12-31

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individual Recipients of living or deceased donor kidney transplant
• Age: ≥ 18 ≤ 80
• The subject must be able to comprehend and sign an approved informed consent form

You may not qualify if…

• Recipients of multiple organ transplant, except kidney-pancreas multiple transplant
• Subjects who are currently participating in a therapeutic clinical trial for transplant rejection
• HIV or Hepatitis C positive patients
• Persons who are known to be pregnant

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States
• Northwestern University — Evanston, Illinois, United States
• University of Maryland — Baltimore, Maryland, United States
• Henry Ford — Detroit, Michigan, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Washington — Seattle, Washington, United States
• CHU Grenoble Alpes Health Center — Grenoble, France
• Bologna University — Bologna, Italy
• Brescia University — Brescia, Italy
• University Hospital Vall d'Hebron, Barcelona — Barcelona, Spain

Full record on ClinicalTrials.gov

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