Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation

Stopped early

Conditions studied: Deep Brain Stimulation, Parkinson Disease, Apraxia, Motor

In brief

Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD). However, it is not known whether DBS can help reduce the signs and symptoms of the limb-kinetic, ideomotor or ideational apraxia associated with PD or if apraxia can exist as a stimulation induced side effect from DBS therapy. In this study, we look to conduct a pilot study to examine the feasibility of characterizing the prevalence of apraxia in PD patients with chronic, stable DBS.

Key facts

Study ID

NCT04725773

Run by

University of Florida

People needed

2

Starts

2021-06-01

Expected to finish

2024-01-28

Last updated by the study team

2025-07-16

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with PD as defined by the UK Brain Bank Criteria
• Male or female, ages 18 to 80 years old
• Chronically implanted DBS of either the STN or GPi for a minimum of 6 months

You may not qualify if…

• Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke)
• History of previous neurosurgical intervention that was not DBS
• Patients with DBS of targets other than the STN or GPi, or leads in both targets
• Patients in whom there is poor manual dexterity for a reason other than PD (e.g. orthopedic injury, amputation)
• Patients with a diagnosis of PD dementia

Where it is running

• UF Health at the University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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