Testing FIRST in Youth Outpatient Psychotherapy

Running, not enrolling · Not applicable

Conditions studied: Anxiety, Depression, Trauma, Behavior Problem

In brief

The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.

Key facts

Study ID

NCT04725721

Run by

Harvard University

People needed

212

Starts

2021-09-27

Expected to finish

2027-02-01

Last updated by the study team

2026-04-17

Who can join

Age: 7 and older, up to 15. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ages 7.0-15.9 years
• at least one clinically-relevant CBCL subscale score indicating borderline/clinical-range anxiety, depression, conduct problems, or post-traumatic stress
• English fluency indicated by taking all school classes in English

You may not qualify if…

• current suicide risk, operationalized as active suicidal ideation or a history of suicide attempt or inpatient hospitalization for suicide risk within the last 3 months
• presence of an eating disorder, schizophrenia spectrum disorder, autism spectrum disorder, or intellectual disability requiring special class placement in school
• referral for ADHD if specifically and exclusively to address inattentiveness and/or hyperactivity-impulsivity

Where it is running

• Harvard University — Cambridge, Massachusetts, United States
• University of Texas at Austin — Austin, Texas, United States

Full record on ClinicalTrials.gov

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