CHronic Nonbacterial Osteomyelitis International Registry

Recruiting now

Conditions studied: Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis

In brief

The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.

Key facts

Study ID

NCT04725422

Run by

Seattle Children's Hospital

People needed

2000

Starts

2018-08-01

Expected to finish

2050-08-01

Last updated by the study team

2024-07-30

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Age at enrollment is equal to or younger than 21 years of age
• Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment
• Whole body imaging evaluation (either WB MRI or bone scintigraphy)
• Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis

You may not qualify if…

• - History of or current malignancy
• Current infectious osteomyelitis
• Contraindication to the selected treatment agent

Where it is running

• Seattle Children's Hospital — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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